The Government was criticised tonight by residents and a pressure group opposing the project for offering help "to virtually nobody".
Of 455 applications, 299 have been refused, 113 accepted, and the rest are being considered.
Hilary Wharf, director of HS2 Action Alliance said: "The rules of the exceptional hardship scheme are being drawn far too tightly. This is a compensation scheme that the evidence shows is simply not fit for purpose, It offers compensation to virtually nobody and this is despite the hundreds of thousands homes blighted, many rendered unsellable, with only a tiny fraction of people qualifying for the scheme.
"HS2 is causing enormous stress and worry as it destroys the value of people's homes and wrecks the plans that they have made for themselves. Government talk of generosity is a cynical misrepresentation of the reality that they don't care."
The hardship scheme requires applicants to prove a pressing need to move.
They have been trying to sell the house for two years but purchasers are put off by the impact of the HS2 link which is 350 yards away. One criterion for compensation is a change in family circumstances, said the businessman. "If our situation is not a change in family circumstances, I don't know what it," he said.
The Government says the compensation scheme is for exceptional hardship and is currently only open to people affected by the HS2 route from London to Birmingham. The scheme will also open to those in phase two, from Birmingham to Leeds and Manchester but is currently in a consultation phase. Officials said the scheme goes over and beyond what the Government has to do - and a longer term compensation scheme will also be looked at later in the year.
Transport Minister, Simon Burns, said: "The Exceptional Hardship Scheme (EHS) is working well - so far there have been 113 successful applications and we have already spent over £48 million purchasing 81 homes along the first phase of the route between London and Birmingham at their full un-blighted market value. The scheme's criteria is clear, but we are applying this in a flexible and compassionate way."