The number of antidepressants given to patients has doubled over the last decade, new figures show.
Between 2005 and 2015 the number of the drugs prescribed and dispensed in England rose from 29.4 million to 61 million.
Meanwhile the latest figures from the Health and Social Care Information Centre (HSCIC) also show that the number of drugs dished out for diabetes has almost doubled at a cost of almost £1 billion a year.
In 2015, there were 49 million oral anti-diabetic drugs, insulins and monitoring devices handed out to patients with diabetes with a "net ingredients cost" (NIC) of £936.7 million for the NHS - before taking into account any money reclaimed.
This is a steep rise from 2005 when 26.5 million diabetes drugs were prescribed at a cost of £495.3 million.
The NIC of drugs to treat depression was £284.7 million in 2015, the HSCIC figures show.
The HSCIC data also show that in 2015 the total number of drugs prescribed and dispensed in community settings across England totalled more than one billion.
Almost nine in 10 drugs were dispensed to those eligible for free prescriptions including the elderly and children.
An NHS England spokeswoman said: "The latest figures for prescribing and dispensing prescriptions show a rising demand and associated costs to treat a range of conditions such as diabetes, cardiovascular, mental health and gastrointestinal issues.
"These data provide a snapshot of the host of medications used to treat the nation's health.
"Whilst there has been a fall in antibiotic prescribing, which is to be welcomed, there has been a rise in the use of antidepressants which reinforces the vital work of prescribers, including dentists, nurses and pharmacists, working closely with patients every day to ensure the best outcomes for individuals and to protect precious NHS resources."
Commenting on the figures, Gillian Connor, head of policy at the charity Rethink Mental Illness, said: "The reasons for this increase in antidepressant prescriptions could include a greater awareness of mental illness and more willingness to seek help.
"However, with our overstretched and underfunded mental health services, too often antidepressants are the only treatment available.
"One in 10 of us will experience depression at some point in our lives. What we want to see is people experiencing depression offered the full range of treatments available, including talking therapies.
"People have to be able to access the treatment that is right for them, whether it's antidepressants, therapy or a combination of the two."