The Canadian actor - who died at the age of 54 on Saturday 28th October 2023 after being found unresponsive in the jacuzzi at his Los Angeles home - played the sarcastic and grouchy but kind and generous friend for 10 seasons of the cult 90s sitcom.
For Friends fans, Perry will always be remembered as Chandler - his adorable bromance with best friend Joey, his hilarious resentment of his job a data analyst, his sweet marriage to Monica, his relish of smoking and his risque fling with an old school friend played by Julia Roberts.
But Perry had many other acting roles outside of Friends, here we take a look at his most memorable moments on screen.
Fools Rush In (1997)
Perry's first big movie role after becoming a household name thanks to Friends. He played a character very similar to Chandler who has a one night stand with a flamboyant, feisty arty-type played by Salma Hayek.
When she finds out she is pregnant they try to make a go of things and prove opposites attract.
The Whole Nine Yards (2000)
In this comedy Perry played a suburban dentist who finds himself caught up in the mafia when a gangster, played by Bruce Willis, moves in next door.
The film was a hit and spawned a sequel. But Willis was unsure of the movie's potential to be a success and so Perry made a bet with him on set that he believed it would top the box office which it did for several weeks.
As a result of losing his bet Willis had to make a cameo in Friends as Rachel's boyfriend with anger issues, Paul.
Away from the screen and movie set, Perry and Willis became real friends and he has said the Die Hard star was his favourite cameo star on the show.
The movie is available to watch on Netflix.
The West Wing (2003)
Perry demonstrated his serious side as a Republican lawyer in political drama The West Wing, appearing for three episodes.
The comedic star's performance as Joe Quincy earned him an Emmy nomination for Outstanding Guest performance in a drama series two years running.
The West Wing is free to stream on Channel 4.
Studio 60 On The Sunset Strip (2006)
Perry reverted back to type in Aaron Sorkin's comedy drama about the production of a live comedy sketch show.
He played Matt Albie, an apathetic comedy writer with an awkward romantic history, who was also a loyal friend.
The show was cancelled after one season but is avaliable to buy or rent on Amazon Prime Video.
17 Again (2009)
This age swap movie starred Disney heartthrob Zac Efron as Mike O'Donnell who gets the chance to rewrite his life when he find himself a teenager again.
Perry played the adult version of teen hero Mike - a seasoned pro at portraying a disgruntled middle aged man, who audiences just can't help liking.
Film 17 Again can be streamed on Netflix.
Mr Sunshine (2011)
This single-camera sitcom was a pet project for Perry - who created, produced and co-wrote the show.
He starred as Ben Donovan, manager of sports and events arena The Sunshine Centre
The comedy was cancelled during its first season due to low ratings. It was released on DVD, including four unaired episodes and is currently available to buy on Amazon Prime Video.
Go On (2012)
Another comedy series Perry produced as well as starred in saw him play Ryan King, a sports talk radio host returning to work after the death of his wife.
The sitcom explored themes of grief and group therapy and is available to watch on Roku.
The Odd Couple (2015-2017)
More than 10 years after Friends ended and said goodbye to the bromance of Chandler and Joey, Perry created this new sitcom about best friends Oscar and Felix co-starring Thomas Lennon.
Former college buddies Felix and Oscar find themselves moving back in together 20 years later after they both split from their wives.
Perry took on some of Joey's traits in Oscar as a disorganised womaniser.
The comedy earned him two People's Choice nominations and ran for three series. It is available to watch on Amazon Prime Video.
The Kennedys: Decline and Fall (2017)
Perry's final television role saw him play politician Ted Kennedy, brother of former US President JF Kennedy.
The two-part miniseries, also known as The Kennedys: After Camelot was a follow up to 2011 drama The Kennedys and starred Katie Holmes as Jackie O.
Holmes confessed to Perry during promo for the show that she was a huge Friends fan and was very excited to work with him.
The show is available to watch on Apple TV.
Read more: Matthew Perry
Matthew Perry 911 call audio released as cause of death probed (Independent, 1 min read)
Matthew Perry Wanted to Be Remembered for Helping Others Get Sober (Variety, 2 min read)
Friends’ team pay tribute to Matthew Perry (Deadline, 2 min read)
Watch: Matthew Perry wanted to work in Friends writers' room