She added: "I don't feel like men are at the same place women are right now. I have really good men friends, but I just feel when it comes to emotional maturity in relationships that men and women are seemingly in different spots."
The Basic Instinctstar is mother to three adopted sons, Roan, 20, Laird, 15, and 14-year-old Quinn.
Stone told Barrymore she was trying to teach her sons about "misunderstandings" surrounding power, masculinity and "what it means to be important" to ensure they have healthy relationships in their lives.
While she may currently be single, the mother-of-three has been married twice, first to producer Michael Greenburg from 1984 until 1990 and then to newspaper editor Phil Bronstein from 1998 to 2004.
She and Bronstein adopted her eldest son Roan together.
Stone got into a bit of trouble last year while looking for love on dating app Bumble after her account was blocked when it was reported as a fake.
A spokesperson for the app later confirmed Stone had been unblocked after she posted about the incident on Twitter.
Director and president of the jury David Lynch poses with actress Sharon Stone during a photocall at the Palais des Festival during the 55th Cannes Film Festival.
Sharon Stone a évoqué sa rupture d'anévrisme au début des années 2000 qui a provoqué son absence à Hollywood et s'est risquée à une drôle de comparaison...
"Perdi todo lo que tenia
Sharon Stone arriving at the 74th Annual Academy Awards (Oscars) at the Kodak Theatre in Hollywood, Los Angeles. Sharon is wearing a dress by Versace.
John Travolta and Sharon Stone at the 74th Annual Academy Awards (Oscars) at the Kodak Theatre in Hollywood, Los Angeles.
From left to right; Sharon Stone and Rosanna and Patricia Arquette arrive for the premiere of the documentary film 'Searching for Debra Winger', as part of the 55th Cannes Film Festival at the Palais des Festivals in Cannes.
Actress Sharon Stone arrives at the Palais des Festival for the Premiere of the animated film 'Spirit' during the 55th Cannes film Festival.
American actress Sharon Stone arriving at Le Moulin de Mougins, Cannes, France, for the amfAR (American Foundation for AIDS Research) 'Cinema Against AIDS Cannes 2002' event.
Jury member, actress Sharon Stone attending the closing ceremony of the 55th Cannes Film Festival at the Palais des Festival.
Actress Sharon Stone filming on location in Islington, north London, on the set of her latest film 'A Different Loyalty'.
Actress Sharon Stone and actor Lambert Wilson arrive for the world premiere of the final instalment of the Matrix triology 'Matrix Revolutions', at the Disney Concert Hall in Los Angeles.
Sharon Stone arriving at the amFar gala Dinner at Le Moulin de Mougins Cannes
Christina Aguilera and Sharon Stone at the MTV Movie Awards 2004, Los Angeles. Doug Peters/allactiondigita
Actresses Halle Berry (right) and Sharon Stone during a photocall to promote their latest film Catwoman, held at the Dorchester Hotel, central London.
Star of the film Sharon Stone arrives for the European premiere of Catwoman at the Vue cinema in Leicester Square, central London.
Director Michael Moore and actress Sharon Stone during the VH1 'Big in 04' awards ceremony at the Shrine Auditorium in Los Angeles. The third annual special, which celebrates the successes of the year in the US, UK and Europe, premieres on VH1 on Sunday 5 December 2004.
Sharon Stone and David Morrissey.
Actress Sharon Stone.
Sharon Stone attending the film premiere of Star Wars Episode III: Revenge of The Sith at the 2005 Cannes Film Festival. Doug Peters/allactiondigital.com
Sharon Stone arrives for the world premiere of her new film, 'Basic Instinct II', at the Vue, Leicester Square, central London, Wednesday 15 March 2006. See PA story SHOWBIZ Stone. PRESS ASSOCIATION Photo. Photo credit should read: Ian West/PA
Sharon Stone arriving.
AP OUT: Sharon Stone arrives at Cinema Against AIDS 2006, the annual event in aid of amfAR (American Foundation for AIDS Research), at Le Moulin de Mougins, during the 59th International Cannes Film Festival.
Sharon Stone arrives for the annual Vanity Fair Party at Mortons Restaurant, Los Angeles.
Sharon Stone arrives for the screening of the 60th Anniversary Film of the Cannes Film Festival. Picture date: Sunday 20 May 2007. Photo credit should read: Anthony Harvey/PA Wire
Sharon Stone arrives for the screening of 'I Am Because We Are' during the 61st Cannes Film Festival in Cannes, France.
Sharon Stone arriving at the amfAR's Cinemas Against Aids 2008 dinner in Mougins, France on May 22, 2008 in Mougins, France.
Sharon Stone arriving for the 2009 British Academy Film Awards at the Royal Opera House in Covent Garden, central London.
Sharon Stone leaving the 17th annual Sir Elton John AIDS Foundation Oscar Party held at the Pacific Design Center in West Hollywood, California, USA.
Sharon Stone arrives at the Inglourious Basterds premiere at the Palais Des Festivals during the 62nd International Cannes Film Festival.
Sharon Stone arriving for the 83rd Academy Awards at the Kodak Theatre, Los Angeles.
Sharon Stone arrives at Mikhail Gorbachev's 80th Birthday Gala at the Royal Albert Hall in London on March 30,2011.
Sharon Stone is seen at JFK Airport in New York City.
Sharon Stone arriving for amfAR's 20th Cinema Against Aids Gala, Hotel Du Cap, Eden Roc. Part of the 66th Festival De Cannes.
Sharon Stone attending the amfAR Gala, Hotel Du Cap, Antibes, part of the 67th Festival de Cannes.
NASHVILLE, TN - NOVEMBER 2: Sharon Stone at the 50th Annual CMA Awards at the Bridgestone Arena on November 2, 2016 in Nashville, Tennessee. (Photo by Scott Kirkland/PictureGroup) *** Please Use Credit from Credit Field ***
Jeff Bridges, Sharon Stone at the Jeff Bridges Hand and Foot Print Ceremony at the TCL Chinese Theater IMAX in Hollywood, CA on January 6, 2017. (Photo by David Edwards) *** Please Use Credit from Credit Field ***
BEVERLY HILLS, LOS ANGELES, CA, USA - FEBRUARY 28: Actress Sharon Stone wearing a Georges Chakra jumpsuit arrives at The Women's Cancer Research Fund's An Unforgettable Evening Benefit Gala 2019 held at the Beverly Wilshire Four Seasons Hotel on February 28, 2019 in Beverly Hills, Los Angeles, California, United States. (Photo by Xavier Collin/Image Press Agency/Sipa USA)