The 44-year-old comedian filmed the special in March and revealed he made the decision to remove jokes about handwashing and social distancing from the routine before it air, in light of the global pandemic.
McIntyre told Jessie Ware's Table Manners podcast: "'I did a joke about it [coronavirus].
"I introduced myself on stage when all the handwashing stuff was starting and I said, 'Ladies and gentlemen, please put your hands together and wash them for 30 seconds as we welcome Michael McIntyre.'
"I actually came on and said, 'This could be the last time we get together in a crowd.'
Michael McIntyre (right) in the stands during the UEFA Champions League quarter final second leg match at the Etihad Stadium, Manchester.
Michael McIntyre and Prince Edward in the stands during the ICC Cricket World Cup group stage match at Lord's, London.
Kim Cattrall presents Michael McIntyre with the award for Best Entertainment Performance in the winners photo area at the Virgin British Academy Television Awards (BAFTA) held at the Royal Festival Hall, Southbank, London. Photo credit should read: Doug Peters/ EMPICS Entertainment
Kitty McIntyre and Michael McIntyre attending the Virgin Media BAFTA TV awards, held at the Royal Festival Hall in London. Photo credit should read: Doug Peters/EMPICS
The Prince of Wales meets Michael McIntyre at the annual Prince's Trust Awards at the London Palladium.
Michael and Kitty McIntyre in the royal box on centre court on day eleven of the Wimbledon Championships at the All England Lawn Tennis and Croquet Club, Wimbledon.
Michael McIntyre performing on stage at the Royal Albert Hall in London for the Teenage Cancer Trust annual concert series. Picture date: Wednesday March 29th, 2017. Photo credit should read: Matt Crossick/ EMPICS Entertainment.
(left to right) Chris Martin, Rosamund Pike and Michael McIntyre during the filming of the Graham Norton Show at The London Studios, south London, to be aired on BBC One on Friday evening.
Michael McIntyre arrives at a Halloween party hosted by Jonathan Ross at his house in north London.
(left to right) Boris Johnson, Jonathan Ross, Jimmy Carr, Andy Murray, Ross Hutchins, Tim Henman, Richard Branson, Eddie Redmayne, and Michael McIntyre take part in a celebrity tennis match in aid of the Royal Marsden Hospital at The Queen's Club, London.
Michael McIntyre with winner of the Writer of the Year award Dawn French, at the 2011 Glamour Women of the Year Awards in Berkeley Square, London.
Michael McIntyre and wife Kitty arriving for the Philips British Academy Film Awards aftershow party, at The Natural History Museum, London.
Comedians (front row left to right) Bill Bailey, Michael McIntyre, Alan Carr, Shappi Khorsandi, and Jack Dee (second row 2nd left), Lee Evans (centre left), John Bishop (second row 4th right), Jack Whitehall (second row 2nd right) and members of Stomp during a photocall for the launch of Channel 4's Comedy Gala at the O2, in aid of Great Ormond Street Hospital, in central London.
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"I said it as a joke! I should never have said that."
Ware asked: "Does it stay in the Netflix special?"
McIntyre admitted: "No, I took all that stuff out. There are a few more jokes in the Netflix special which I'm hoping are still funny but it's worried me slightly. 'I have jokes about face masks, but this was at a time no one in the world except people in Asia were wearing face masks."