Ewan McGregor is said to have split from his wife Eve Mavrakis after 22 years of marriage.
Family sources confirmed to respected publication People the pair had separated in May.
News of their relationship breakdown comes after the father-of-four was pictured kissing his Fargo co-star Mary Elizabeth Winstead in a London pub in a Sunday newspaper.
The Scottish actor, 46, and French wife Mavrakis, 51, wed in 1995 and have four children together, Clara, Esther, Anouk and Jamyan.
American actress Winstead, 32, separated from her husband, writer and director Riley Stearns in May.