Kate Beckinsale said she is hopeful that hiring female film directors will no longer be "unusual" in the coming years.
The British actress appeared at New York Comic Con to promote her new movie Underworld: Blood Wars, the fifth instalment in the film series about the vampire warrior Selene.
Kate, 43, said she welcomed that the movie was directed by German film-maker Anna Foerster, who is making her directorial debut.
"I'm all about as many vaginas being involved as possible," Beckinsale told the audience.
"I have to say I don't think that gender has a lot to do with whether you're a good director or a bad director.
"I know it always comes up quite a lot with this because it's an action heroine which used to be unusual but is now less unusual.
"I'm hoping in a few years the conversation about female directors being unusual will be slightly less unusual too."
Addressing the crowd at Madison Square Garden, Kate said her favourite villain from the Underworld film series was Lucian played by Michael Sheen, the father of her 17-year-old daughter Lily.
She said: "My favourite adversary is my baby daddy Michael Sheen - in life and in movies."
Kate also revealed the producers of the Underworld films had wanted to make a film which also featured the vampire-hunter Blade.
"They said no," she said. "We had that idea. Too late. They're doing something with Blade."
Underworld: Blood Wars is due out in UK cinemas in February 2017.