The creator of Transparent called Donald Trump an "inheritor to Hitler" after winning an Emmy Award for the hit Amazon series.
Jill Soloway, who was honoured for comedy directing at the ceremony in Los Angeles, described the Republican presidential candidate as "the most dangerous monster to ever approach our lifetimes".
Speaking backstage, she told reporters: "Jews were otherised in Nazi Germany to gain political power for Hitler. Right now Donald Trump is doing the same thing. He's otherising people.
"He calls women pigs if they don't look like beauty pageant contestants. He blames Muslims and Mexicans for our problems. He makes fun of disabled people.
"This is otherising with a capital O. It has been used in our history before to start and win wars.
"He needs to be called out at every chance ... for being one of the most dangerous monsters to ever approach our lifetimes.
"He's a complete dangerous monster and any moment that I have to call him out for being an inheritor to Hitler I will."
During her speech on-stage, she also told the audience to "topple the patriarchy".
She said: "I've always wanted to be part of a movement. This TV show allows me to take my dreams about unlikeable Jewish people, queer folk, trans folk, and make them heroes. Thank you to the trans community for your lived lives."
While backstage, she spoke alongside the star of Transparent, Jeffrey Tambor, who won the Emmy for best comedy actor for the second year in a row.
He urged the film and television industry to provide more opportunities for transgender talent.
"I would not be unhappy were I the last cisgender male playing a female transgender on television," Tambor said.