Drake may miss out on equalling Bryan Adams' 1991 record for the most consecutive weeks at No.1 in the UK singles chart.
His 15-week reign with One Dance could be ended by Ed Sheeran and Justin Bieber.
If so, he will just fail to match the 16 weeks at the top of the chart logged by fellow Canadian's (Everything I Do) I Do It For You, from the soundtrack to the Kevin Costner film Robin Hood: Prince Of Thieves.
Justin and Danish singer MO feature on Cold Water, the new single by electronic act Major Lazer, which has been co-written by Ed and Benny Blanco.
Cold Water is sitting at No.1 in the Official Chart Update following its release on Friday.
Rapper Drake has taken a dramatic tumble to No.5.
The rest of the top five is made up of Jonas Blue's Perfect Strangers at No.2 and The Chainsmokers' Don't Let Me Down one place below.
Britain's Got Talent contestant Calum Scott is at No.4 with Dancing On My Own.
In the album chart, rock band ELO are on track to score their first No.1 in 35 years with hits retrospective All Around The World - The Very Best Of.
A decade after its original release, the collection recently passed the million-sales mark following the performance of Jeff Lynne's ELO at Glastonbury.
The band last reached No.1 with Time in August 1981.
British alt rockers Bear's Den are set for a new personal best, with second album Red Earth & Pouring Rain at No.2.
Christine & The Queens' Chaleur Humaine holds firm one place behind.
Adele's 25 is down to No.4 on the update.
Coldplay's A Head Full Of Dreams rounds off the top five.