The Duchess of Cambridge is to present the Art Fund Museum of the Year award at a dinner at the Natural History Museum in London.
Kate will join artists including Antony Gormley, Grayson Perry, Michael Craig-Martin and Cornelia Parker at the prize giving event.
Some 370 guests from the arts and culture sector will sit down with the Duchess in the central Hintze Hall, with tables set around "Dippy" the dinosaur - the museum's famous Diplodocus skeleton.
The £100,000 award - the largest museum prize in the world - is given annually to one outstanding museum which has shown exceptional imagination, innovation and achievement.
The five organisations on the shortlist for 2016 are: Arnolfini, Bristol; Bethlem Museum of the Mind, London; Jupiter Artland, West Lothian; Victoria and Albert Museum, London; and the York Art Gallery, Yorkshire.
Kate, who is patron of both the Natural History Museum and the National Portrait Gallery, will also meet representatives from the museums with Art Fund director Stephen Deuchar.
The Art Fund is the national fundraising charity for art, and in the last five years has given £34 million to help museums and galleries acquire works of art for their collections.