Cambridge will look to end their winless run in Sky Bet League Two when Colchester visit on Tuesday.
The U’s have not tasted success in the division since November 3 – a run of five games – and lost away to Forest Green on Saturday.
Head coach Mark Bonner has no new injury concerns, with Liam O’Neill a long-term absentee due to a hamstring issue.
Meanwhile on-loan MK Dons midfielder Hiram Boateng is set to spend the next two months on the sidelines after surgery on a dislocated shoulder.
Colchester boss Steve Ball made a triple substitution to help his team fight back and earn a 1-1 draw at Port Vale last weekend.
Courtney Senior, Michael Folivi and Luke Gambin were introduced and will hope to have done enough to secure a starting berth at Cambridge.
Tom Lapslie remains absent with a hamstring issue and young midfielder Diaz Wright has also suffered a setback with his knee injury.
Captain Harry Pell has not featured so far this month due to a knee problem picked up during training.