Donald Trump has said the Duchess of Sussex is taking press coverage "very, very personally" and suggested "you have to be a little bit different than that".
The US President lavished praise on the Queen, the Prince of Wales and Meghan's husband the Duke of Sussex during a wide-ranging radio interview.
Mr Trump, who was treated to the pomp and pageantry of a state visit earlier this year, said the Royal Family are "really special people".
In the interview with Nigel Farage on LBC, he was asked about Meghan in light of the duchess having recently spoken about the difficulties she has faced over the past year as a royal.
Mr Trump was asked by Mr Farage if he feels sorry for Meghan "given what the press are saying about her", and the President said: "Well I've been watching her interviews, and I've seen it and she's taking it very personally.
"I guess you have to be a little bit different than that. But she takes it very, very personally, and I can understand it.
"But I don't know her. I will say I met Harry. He's great. I met him when I was over."
Meghan appeared alongside Harry in the ITV documentary Harry & Meghan: An African Journey, where she described her past year as a member of the Royal Family as "hard".
She said she tried to cope with the pressures of her new life since marrying Harry in May 2018 by putting on a "stiff upper lip".
But she said she was not prepared for the intensity of the tabloid interest.
Meghan has been a vocal critic of Mr Trump in the past and backed his political rival Hillary Clinton.
On the eve of his state visit to the UK, Mr Trump denied calling the duchess "nasty".
Before the 2016 presidential election Meghan suggested she would leave the US if the former reality TV star Mr Trump won.
In an interview with The Sun newspaper, Mr Trump claimed he was unaware of Meghan's comments and said: "I didn't know that. What can I say?
"I didn't know that she was nasty."
But in a tweet, the president denied making the comment, saying: "I never called Meghan Markle 'nasty'. Made up by the Fake News Media, and they got caught cold!"
In his LBC interview, broadcast on Thursday evening, Mr Trump said of the Queen and her son: "She's a great woman. I say that very seldom. I don't say that often, I have to say, about anybody.
"But she is really very outstanding, and Prince Charles, so good, so good. He loves the environment. He loves your country so much. We had a great time, we'll get together. Really special people."