The Duke of Cambridge will commemorate the millions of Jews who died during the Second World War when he lays a wreath at Yad Vashem, the World Holocaust Remembrance Centre.
William, who is making a five-day visit to the Middle East, will receive a short tour of the museum before meeting with two Holocaust survivors of the Kindertransport who will share their personal experiences with him.
The duke will be joined by Chief Rabbi Ephraim Mirvis during his visit, when he will leave his floral tribute in Yad Vashem's Hall of Remembrance.
The duke will then travel to the residence of Israel's Prime Minister Benjamin Netanyahu where he will be welcomed to Israel by the politician and his wife before meeting the country's President Reuven Rivlin at his residence.
Later William will visit the city of Jaffa where he will meet young people involved in the work of two organisations focused on co-existence through football between the youngsters of different religious and ethnic communities - the Equaliser and the Peres Centre for Peace.
He will attend a football event hosted by the two charities and will have a chance to spend time with children and teenagers involved in several of their projects, including one focused on empowering young girls.
In the evening the duke will give a speech at a reception at the residence of Britain's Ambassador to Israel David Quarrey before returning to Jerusalem.