A blaze that ripped through Glasgow's renowned School of Art has been largely contained after causing "extensive" damage to the historic building, the fire service said.
Around 50 firefighters are still working to extinguish the fire, which broke out at around 11.20pm on Friday and spread to the nearby O2 ABC.
It is just four years since the Charles Rennie Mackintosh building was badly damaged in another blaze.
The Scottish Fire and Rescue Service (SFRS) said the building had been "extensively damaged" including multimillion-pound restoration work carried out in the aftermath of the previous fire. No one has been reported injured.
SFRS area manager David Young said: "The fire has now largely been contained, but this remains a protracted incident and our efforts very much continue at this stage to extinguish the fire and ensure the community is protected.
"There will be disruption around Dalhousie Street, Sauchiehall Street and Renfrew Street and I would advise the public to avoid these areas at this present time.
"I would like to thank our firefighters on the ground and our operations control firefighters for working effectively with our partners throughout the night and into today."
Scotland's First Minister Nicola Sturgeon said: "This is a very sad morning in the city of Glasgow. Glasgow School of Art is an institution that is loved not just by its students, staff and the people of this city, but by many around the world.
"First and foremost my thoughts are for the safety of people. At this stage it appears there are no casualties and I hope that continues to be the case.
"The professionalism and bravery of the fire service, and the rest of the emergency services, was once again demonstrated last night. This is clearly an extremely complex and large-scale incident, and one that is ongoing. I would like to thank the emergency services for their continued efforts."
Ms Sturgeon said the Scottish Government was ready to provide "any support that may be required, now and in the period ahead".
Former students at the art school spoke of their disbelief and sadness.
Margaret Archbold, 48, a Glasgow artist who studied fine art at the school and graduated in 1994, said she had come down to the cordons around the building to "say goodbye".
She said: "It just keeps getting kicked in the teeth. It shouldn't have happened again.
"It was graduation day yesterday for this year's students. I just feel really sorry for the fire brigade because they worked so hard to save it the last time.
"I came down to say goodbye actually, I thought there was nothing left, and I was quite an important time in my life. I'm an artist and my uncle's an artist - he studied here too- and I just needed to come and see it."
Sam Patterson, 30, is vice president of the Glasgow Institute of Architects and studied architecture at the art school for five years.
Watching as firefighters hosed the building, he said there was a sense of "disbelief".
Mr Patterson, who graduated in 2012, said: "One of the first architecture books I bought as a first year student about to move to Glasgow was 100 buildings of the 20th century and page one was Glasgow School of Art.
"It's a shocker, especially in Mackintosh's 150th anniversary and so close to being completed.
"It's difficult really to say much until there's an evaluation or report on the building but certainly the spread of the fire is far greater than previous years and from what I can see walking around this morning it's going to be a far more challenging project to redo."
Isabel Garriga, president of the institute, said: "The Glasgow Institute of Architects woke up this morning to hear the most horrific news about one of the most beloved iconic buildings in Glasgow, a building that is a lot more than a building, an architectural masterpiece, a place we love deeply, a place where a lot of us have studied, worked and grown as architects.
"The sad news that the Glasgow School of Art was ravaged once again, when it was finally recovering from the fire four years ago has shaken all of us and we would like to offer our full support to the Art School in these dark times."
Earlier, SFRS deputy assistant chief officer Peter Heath said the fire had "spread very rapidly".
"(The fire) reached from the ground floor right through to the roof. It is significantly damaged," he said.
The blaze was a "devastating loss for Glasgow", with firefighters dealing with a "sense of loss" along with the city's people, he said.
A restoration project, which was set to cost between £20 million and £35 million, had been returning the famous art school to its former glory after a devastating fire in 2014, with Brad Pitt and Peter Capaldi among those lending their support.