The North of England's first ever direct flights to India's financial capital Mumbai will begin in November.
Indian airline Jet Airways announced it will operate a four flights per week service from Manchester.
International Trade Secretary Liam Fox said the new route will "strengthen connections between two major global cities and the wider Northern Powerhouse".
More than half a million people of Indian origin live in northern England, while over 100 Indian companies have bases across the region.
The flights follow the launch of the Manchester-India Partnership created earlier this year to boost links.
Manchester Airport chief executive Andrew Cowan said: "We have worked, along with a range of partners, to create a compelling case for why our city - and the wider North - is a great place to visit, invest in and do business with.
"I am delighted Jet Airways have recognised this by launching what I'm sure will be a hugely popular service.
"This route will deliver a major boost to businesses looking to export to the world's fastest-growing economy, as well as helping to attract Indian visitors and investors to the North."
Jet Airways will initially fly from Manchester to Mumbai on Monday, Thursday, Saturday and Sunday using an A330-200 aircraft with 254 seats.