Action-adventure game Hellblade: Senua's Sacrifice, which focuses on the main character's battle with psychosis, has won five Baftas at the industry awards.
The game, which follows a Celtic warrior's struggle with the condition and was developed with input from neuroscientists, picked up the awards for artistic achievement, British game and game beyond entertainment.
It also triumphed in the audio achievement category, while actress Melina Juergens won the performer award for her role as protagonist Senua.
Mystery game What Remains Of Edith Finch claimed the award for best game at the ceremony in London, which was hosted by comedian Dara O'Briain.
Elsewhere, Super Mario Odyssey - the critically acclaimed 3D platform game for the Nintendo Switch - picked up two awards for game design and family game.
Another Nintendo title, The Legend Of Zelda: Breath Of The Wild, won the Bafta for game innovation.
Popular PlayStation exclusive Horizon Zero Dawn won the original property award, and online multiplayer shooter Overwatch collected the evolving game prize.
There were also wins on the night for Golf Clash in the mobile game category, and hand-drawn puzzle game Gorogoa was named best debut game.
Cuphead, the 2D 'run and gun' indie game styled on the cartoons of the 1930s won the music award, while Divinity: Original Sin 2 won the multiplayer award.
Adventure game Night In The Woods completed the line-up of winners on the night, taking home the ward for narrative.
The Bafta Fellowship was presented to game designer Tim Schafer in recognition of his creative contribution to the industry, best known for creating Grim Fandango and his work on The Monkey Island series.