After 12 years together and two years of marriage, film stars Brad Pitt and Angelina Jolie - otherwise known as "Brangelina" - are set to divorce.
Here is a timeline of the rise and fall of their relationship:
Angelina Jolie and Brad Pitt met on the set of action comedy film Mr & Mrs Smith, while Brad was still married to Friends star Jennifer Aniston. Angelina had recently divorced Billy Bob Thornton.
Both movie stars denied rumours that they had begun an affair during filming, insisting their romance began later.
Brad and Jennifer announced their decision to split after nearly five years of marriage.
Jennifer then filed for divorce, citing "irreconcilable differences".
Brad, Angelina and her adopted son Maddox were pictured holidaying together in Kenya, fuelling rumours of a relationship.
Brad and Angelina posed for a photo shoot entitled "Domestic Bliss", but did not confirm their relationship officially. Later that month, Angelina adopted daughter Zahara Marley from an orphanage in Ethiopia.
Brad and Jennifer finalised their divorce.
Angelina confirmed she was pregnant with her first child with Brad. Her children's surnames were changed to Jolie-Pitt and her film star partner legally adopted Maddox and Zahara.
The couple welcomed their first biological child, daughter Shiloh Nouvel Jolie-Pitt.
Brad told Esquire magazine that he and Angelina would only marry "when everyone else in the country who wants to be married is legally able", backing same-sex marriage. Brad reaffirmed this in 2011, when New York passed marriage equality legislation.
Angelina adopted three-year-old Pax from an orphanage in Vietnam.
Angelina gave birth to twins - a son Knox Leon and a daughter Vivienne Marcheline - completing their family.
The couple won a privacy case against the News of the World over false allegations that they were separating.
Angelina revealed to Christiane Amanpour that the couple's six children were keen for her to get married. She said: "We've explained to them that our commitment when we decided to start a family was the greatest commitment you could possibly have. Once you have six children, you're committed."
Brad indicated he would be open to marrying, telling The Hollywood Reporter: "It seems to mean more and more to our kids. We made this declaration some time ago that we weren't going to do it till everyone can. But I don't think we'll be able to hold out. It means so much to my kids, and they ask a lot. And it means something to me, too, to make that kind of commitment."
Angelina underwent a double mastectomy after discovering that she carries a genetic mutation dramatically increasing her chances of cancer. She later had her ovaries removed.
The couple wed at their estate in the south of France in a private ceremony. Angelina wore a dress covered in drawings by their six children.
Brangelina made their final official public appearance at the premiere of their movie By The Sea, which flopped. It told the story of a couple - played by Brad and Angelina - as they tried to repair their troubled marriage.
She told The Telegraph: "Brad and I have our issues, but if the characters were even remotely close to our problems we couldn't have made the film.
"To be clear: we have fights and problems like any other couple. We have days when we drive each other absolutely mad and want space, but the problems in the movie aren't our specific problems."
A lawyer for Angelina confirmed she had filed for divorce.