For Gina Short, winning a million dollars in the first Ultimate Millions second chance drawing means a fresh start as she continues her fight against breast cancer.
The North Carolina Education Lottery posted a video to Twitter of her surprised reaction and collapsing to the floor after hearing the news.
Short's entry was drawn by more than 1.2 million entries and she learned about her huge win during a visit to lotto's Charlotte regional office.
She said she had a hard time believing her good luck and that winning the prize means a lot to her because of her cancer diagnosis six years ago.
She claimed her prize with her husband Len by her side, as he has been during multiple surgeries and treatments.
Short chose the lump sum payment and after the tax withholdings received more than $415,000.
Short told FOX 35: "I have a second chance. That's what my whole life is about, second chances."
She added: "If you would have told me, in a million years I still wouldn't have believed you.
"I would have said, 'No you've got the wrong girl,' because that's what I said to them when they told me I had cancer, 'No you've got the wrong girl.'"
Short also paid tribute to her husband Len, saying: "I might have gone through the breast cancer, but this is the guy that told me not to run.
"I wanted to give up, but he would not let me give up."
Biggest UK lottery winners
Woman fighting cancer wins $1 million in the lottery
Colin and Chris Weir, from Largs in Ayrshire scooped 161 million in the EuroMillions draw after several rollovers in 2011. They are the biggest British lottery winners in history.
Adrian Bayford, who won an astonishing £148m on the Euromillions with his wife Gillian, had to shut up the music shop he owns, because people targeted it with requests for money.
One British ticket won £113,019,926 in October 2010 but decided not to go public.
Car mechanic and racing driver Neil Trotter scooped a staggering £107.9 million jackpot on the Euromillions lottery in March 2014.
Dave and Angela Dawes won £101 million on the EuroMillions in 2011. It was only the third time the couple, from Wisbech, Cambridgeshire, had played the lottery. The couple are said to have since split up.
The sum was won in May 2010 but the winner kept their identity a secret.
One lucky British ticket-holder picked up a £81million EuroMillions rollover but remained anonymous.
Nigel Page and Justine Laycock from Cirencester bagged a £56 million jackpot back in February 2011. On winning the jackpot, Page said: 'I'd already checked my National Lottery account and had seen I'd won £55 on Lotto when I decided to buy two Lucky Dips for the big EuroMillions jackpot on Friday.'
One lucky winner won shy of 50 million but chose to remain anonymous.
Les and Sam Scadding from Newport, South Wales, and a syndicate of seven Liverpudlian call-centre workers shared a staggering £91 million in November 2009. Les, an unemployed mechanic, was £68 overdrawn on the day he bought his ticket, while the Liverpool syndicate only started playing EuroMillions together four months before their win.
Carrington, 22, from Stapleford in Nottingham, banked £45 million after matching all five numbers and two Lucky Stars in a EuroMillions draw in February 2012. The Iceland supervisor said she planned to marry painter fiancee Matt Topham, 22, following the Lucky Dip win.
Husband and wife Gareth and Catherine Bull have fairly modest spending plans despite their £40.6 million jackpot win in January. Speaking about what she planned to do now that she was rich, Catherine explained that she intended to use part of their winnings to replace the carpet on her upstairs landing...
Angela Kelly became one of the biggest lottery winners in UK history back in 2007, after scooping a £35 million EuroMillions jackpot. This is estimated to earn £5,000 a day in interest alone, meaning she's unlikely to ever be short of cash.
In June 2009, 74-year-old Brian Caswell got the surprise of his life when he took his lottery ticket to his local newsagent and discovered he'd won almost £25 million.
Belfast housewife Iris Jeffrey, 58, was the lucky holder of the record 20.1 million rollover lottery winning ticket back in 2004.
Jeffrey, 58, a cancer sufferer, only realised three weeks after the draw took place that she had won the jackpot after organisers Camelot pleaded for the person holding the prize ticket to come forward and claim the prize.
Stephen Smith and his wife Ida from Hemel Hempstead, Herts, won nearly 19 million in the National Lottery. Mr Smith said he would give up his winnings if he could have his health and the chance to live a longer life with his wife.