Many passengers will be forced to make multiple changes, use replacement buses and suffer extended journey times. Words: PA.
Revellers attending Reading Festival are set to be hit by strike action from Saturday to Monday by members of the Rail, Maritime and Transport union as First Great Western passengers travelling towards the South West will face reduced services.
Planned works by Southern mean trains will be disrupted from the south coast and Surrey into London from Saturday to Monday.
On Sunday buses will replace trains between Bicester North and Banbury, significantly increasing journey times from the Midlands and Oxfordshire to London.
National Express is adding 67,000 extra seats to its coach network for travellers looking for an alternative method of transport in the face of rail disruption.
A spokesman for the operator said: "Demand for coach services has significantly increased on affected routes and bookings have increased by nearly 30% year-on-year in affected areas."
He added that some journeys, such as from Bournemouth or Poole to Heathrow Airport, would be quicker by coach than train as a result of the rail disruption.
Some 148,000 passengers are set to travel on the Eurostar over the bank holiday weekend, with 38,000 travelling on Friday alone.
Highways England said it was removing more than 400 miles of roadworks from motorways and major roads in a bid to reduce hold-ups.
Some 177 sets of roadworks will be completed or lifted in time for the late August getaway.
The section of the A27 hit by a plane in the Shoreham air disaster is currently closed and diversions could remain in place on the popular coastal road into the weekend.
Bank holiday travel: Rail strikes to cause 'serious disruption'
This Edwardian station was built in the early 1900s and is operated by East Midlands Trains. 59 per cent of people surveyed said they were satisfied with the station - a low score which ranked it bottom for both cleanliness and facilities in the Passenger Focus National Passenger survey.
Birmingham New Street railway station is the largest and busiest serving Birmingham. Despite the regular flow of people, only 64% of passengers surveyed in the National Rail Passenger Survey (NRPS) are satisfied with the sation.
London Bridge railway station is a central London railway station and a London Underground complex in the London Borough of Southwark. The station is the oldest railway station in central London and one of the oldest in the world. 67% of passengers surveyed were satisfied with this station, the fourth busiest station in London.
Peterborough railway station is a major interchange serving both the north-south ECML, as well as East-West long-distance and local services. The station is managed by East Coast. Just 67% of passengers surveyed were satisfied with this station.
Crewe station was completed in 1837 and is one of the most historic railway stations in the world. Like London Bridge and Peterborough, only 67% of passengeres surveyed were happy with this station.
Gatwick Airport station provides a direct rail connection to London. The station platforms are located about 70 metres away from the airport's South Terminal. 69% of passengers surveyed were satisfied with this station.
Stockport railway station was identified as one of the ten worst category B interchange stations by a mystery shopper assessment in 2009. Despite improvements being made to the station since, it is still one of the ten worst stations with only 70% of passengers satisfied with the station.
Clapham Junction station is one of the busiest in Europe by number of trains using it with many routes from London's two busiest termini, London Waterloo and London Victoria. Only 71% of passengers surveyed were satisfied with this busy station.
Maidenhead railway station serves the town of Maidenhead, Berkshire, England. It is served by local services operated by First Great Western from London Paddington to Reading, and is also the junction for the Marlow Branch Line. The survey showed 71 per cent of respondents were satisfied with the overall quality of the station, giving it the ninth lowest satisfaction rating.
Coventry station has the PlusBus scheme where train and bus tickets can be bought together at a saving. Despite this convenient feature, only 72% of passengers surveyed were satisfied with the station.