The UAE based airline topped the list in the site's Traveller's Choice awards, the first time airlines have been included.
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As well as taking home the top prize, the airline also scooped other awards including Best Major Airline - Middle East and Africa, Best Economy Class and Best First Class.
Emirates is the world's largest airline and operates a staggering 126 flights a week between the UK and Dubai.
The awards are based on the quantity and quality of reviews collected over a 12-month period.
Singapore Airlines, Azul from Brazil, the USA's JetBlue and Air New Zealand round out the top five.