Nicolas Sanchez has been replaced at fly-half by Juan Martin Hernandez in one of three changes made by Argentina coach Daniel Hourcade ahead of Saturday's clash with England at Twickenham.
Hernandez moves from inside-centre to partner Tomas Cubelli, who has been selected ahead of Martin Landajo at scrum-half, while in the pack, Leonardo Senatore comes in for Facundo Isa at number eight.
With Sanchez omitted from the squad altogether, 28-year-old Santiago Gonzalez Iglesias has been named on the bench.
The Pumas will be looking to end a frustrating autumn series on a high note after suffering narrow defeats at the hands of Wales and most recently Scotland.
But having won only once in six visits to Twickenham, Hourcade is aware that downing an in-form England side will be a big ask for his players.
He said: "Even though the perfect match doesn't exist, we have to play the best game possible because England are in a great place and they're a very good team.
"Having Hernandez in the starting line-up is always a benefit for the team and of course playing at 10 is a position that he prefers.
"It is not only Hernandez's experience of the game which is important, it is his knowledge, his experience in many situations that is important for the team."