South Africa lock Eben Etzebeth has been ruled out of Saturday's clash with Wales after failing to recover from the concussion he suffered against England earlier this month.
Etzebeth sat out the Springboks' humiliating defeat in Italy over the weekend having sustained the head injury at Twickenham on November 12 and will now return to South Africa.
"We won't call up a replacement because we currently have sufficient cover in that position with Pieter-Steph du Toit, Lood de Jager and Franco Mostert," explained head coach Allister Coetzee.
"There are also some utility forwards who can provide extra cover if needed."
The Springboks remain without a win on their European tour so far.
Following a 31-31 draw with the Barbarians at Wembley, Coetzee's men were beaten 37-21 by England before Saturday's 20-18 loss in Florence.