Still reeling from their embarrassing defeat to South Africa, Australia wielded the axe with six changes for the upcoming Adelaide Test.
In a drastic overhaul to the squad following Australia's humiliating innings and 80-run defeat to the Proteas in the second Test in Hobart, selectors included uncapped quartet Matthew Renshaw, Peter Handscomb, Nic Maddinson and Chadd Sayers in the 12-man team.
Wicketkeeper Matthew Wade and Jackson Bird have also been recalled after Australia lost the Test series to South Africa with a match to spare heading into the day-night match at Adelaide Oval, starting Thursday.
As a result, Joe Burns, Adam Voges (concussion), Callum Ferguson, wicketkeeper Peter Nevill and Joe Mennie dropped out of the squad as Australia attempt to salvage some pride.
Captain Steve Smith was only one of six players to survive the cull as interim national selector Trevor Hohns made his presence felt following the sudden resignation of Rod Marsh amid Australia's struggles.
"Peter's form over the last couple seasons, and with Australia A, has been very consistent. He has a good all-round game and we think he is the type of player who could succeed at the next level," Hohns said on Sunday after some strong performances in the Sheffield Shield.
"Nic is an exciting and talented young player and we feel now is the ideal time for him to be involved with the Australian team. He has the ability to break the game open and we think he will flourish in this environment."
"We consider Chadd and Jackson to be very good bowlers that also can bowl a large amount of overs in conjunction with Mitchell Starc and Josh Hazlewood," he added.
"Chadd bowls very well in Adelaide and Jackson is coming off a strong performance in his last Test match earlier in the year and both deserve their chance."
Wade comes in for Nevill as he returns to the Test squad for the first time since 2013.
Hohns continued: "Matthew has worked extremely hard on his keeping in the past few season and we consider it to have improved substantially. He is also a very valuable player with the bat and will add to the depth in our batting order."
Australia squad: Steve Smith (c), David Warner (vc), Jackson Bird, Peter Handscomb, Josh Hazlewood, Usman Khawaja, Nic Maddinson, Nathan Lyon, Matt Renshaw, Chadd Sayers, Mitchell Starc, Matthew Wade.