Eddie Jones has named Tom Wood and Elliot Daly in England's starting line-up for Saturday's Test showdown with South Africa at Twickenham.
England are looking to make it 10 wins in succession under Jones, who has turned to Northampton flanker Wood and Wasps centre Daly in a bid to end a barren run against the Springboks.
Indeed, England have not beaten their southern hemisphere rivals since 2006.
It represents a tough challenge for Daly on what will be his first international start, as he replaces Jonathan Joseph at outside centre, with the Bath man suffering from a groin problem.
Wood has been out of the England side for over a year, but gets the nod at open-side flanker.
Explaining his decisions, which include naming uncapped trio Kyle Sinckler, Nathan Hughes and Ben Te'o on the bench, Jones said: "We've picked a matchday 23 with a blend of experience and youth.
"We've trained well this week and I am pleased with how the players have come together and responded to some of the things we've asked them to do. The boys are focused and ready to go.
"We're looking forward to the game. It's a fantastic opportunity to show how much depth we have in English rugby. With a few influential players not available for selection this is a great opportunity for some of the new faces to put both feet forward and we're backing them to do the job for us.
"Test matches are always about the contest up front and South Africa pride themselves in the set piece, but we'll be ready for the challenge."
Northampton second-row Courtney Lawes will earn his 50th cap, seven years on from making his debut against Australia.
England team: Mike Brown, Marland Yarde, Elliot Daly, Owen Farrell, Jonny May, George Ford, Ben Youngs, Mako Vunipola, Dylan Hartley, Dan Cole, Joe Launchbury, Courtney Lawes, Chris Robshaw, Tom Wood, Billy Vunipola.
Replacements: Jamie George, Joe Marler, Kyle Sinckler, Dave Attwood, Nathan Hughes, Danny Care, Ben Te'o, Jonathan Joseph.