Exeter Chiefs hooker Luke Cowan-Dickie is unlikely to feature in England's upcoming internationals after suffering a sprained ankle and ligament damage.
England face South Africa at Twickenham on November 12, with Tests against Fiji and Argentina preceding their final match against Australia on December 3.
Eddie Jones is unlikely to be able to select Cowan-Dickie, who sustained an ankle injury in last weekend's European Champions Cup defeat to Clermont Auvergne.
Exeter head coach Rob Baxter told the club's official website: "It's relatively serious. There's no fracture but it does look like a badly sprained ankle with some ligament damage so we're not going to be seeing him in the next few weeks.
"Luke's been playing really well and he's been a high-tempo, high work-rate player for us with great physicality in attack and defence.
"The bigger blow is for him personally as when you're on form when you're a young hooker you want to keep on going and he's been involved in some big games for us."
Cowan-Dickie was part of England's tour to Australia this year and was involved in Jones' training squad in Brighton in September.