Brett Ferres has been ruled out of the Four Nations as hosts England suffered a blow less than two weeks out from their tournament opener.
Leeds Rhinos forward Ferres sustained a calf injury in training and national coach Wayne Bennett concedes he will be sorely missed.
"Brett is a key member of the senior squad and he's hugely disappointed to be missing out," said Bennett, whose side face New Zealand in their first game on October 29.
"He had been working hard with the train-on squad and has continued to do so in our camp. Unfortunately, he suffered this injury in training which has meant he will not be able to train effectively for a few weeks.
"Just like all the other players, I know he was excited about the challenge ahead with England.
"Myself and all the England team wish Brett all the best with his recovery and look forward to seeing him in action next season."
Ferres' club-mate Stevie Ward has been drafted into the 24-man squad, with England, who will be captained by Sam Burgess, scheduled to take on France in a Test match on Saturday.