Philippe Coutinho, Filipe Luis, Fernandinho and Giuliano are the four changes to Brazil's starting XI for their home World Cup qualifier against Bolivia.
Brazil sit second in the South American section of qualifying for Russia 2018, a point behind Uruguay after eight matches.
Their last outing was a 2-1 home victory over Colombia last month, but head coach Tite has been forced into three of his alterations from that starting XI, with the Real Madrid duo of Marcelo and Casemiro injured and Paulinho serving a suspension.
Filipe Luis replaces Marcelo at left-back, while Giuliano and Fernandinho deputise for Casemiro and Paulinho in midfield.
Tite had already confirmed that Liverpool forward Coutinho would be preferred to Chelsea's Willian, making it four alterations for Thursday's meeting in Natal.
Brazil starting XI: Alisson; Dani Alves, Marquinhos, Miranda, Filipe Luis; Fernandinho, Giuliano, Renato Augusto; Philippe Coutinho, Gabriel Jesus, Neymar.