Andy Murray will look to add the US Open title to his Wimbledon and Olympic triumphs at Flushing Meadows next week, while Serena Williams has another chance to make history with a 23rd major success.
Novak Djokovic's surprise early exits at SW19 and Rio 2016 left the door ajar for Murray to go on the longest unbeaten run of his career, while Williams is looking to bounce back from her own Olympics disappointment.
Using data from Opta, we take a look at some interesting facts and figures ahead of the final grand slam of 2016.
- Roger Federer will not be competing in the US Open for the first time since 1999. Federer had appeared in a record 65 consecutive grand slams until his absence from the French Open in May.
- Eleven of the past 12 winners of the men's singles have been European with Juan Martin del Potro's win in 2009 the exception. Prior to this run 10 of the 11 champions had been non-Europeans.
- Novak Djokovic has reached at least the semi-final stage of the last nine US Opens, reaching the final on six occasions (winning twice).
- Rafael Nadal has reached three US Open finals, facing Djokovic on each occasion (winning two, losing one).
- The last four winners of the US Open men's singles have all been different players (Andy Murray, Nadal, Marin Cilic, Djokovic), Federer is the only player to defend his title at the tournament this century.
- If Williams wins at Flushing Meadows this year she will stand alone as the woman with the most grand slam titles in the Open Era (currently tied on 22 with Steffi Graf).
- Angelique Kerber has not made it past the fourth round at the US Open since reaching the semi-finals in 2011.
- Since 1991, Serena Williams holds the record for the most aces served during a single US Open, serving 70 over the course of the tournament in 1999.
- Defending French Open champion Garbine Muguruza has never made it past the second round of the US Open in three attempts.
- Williams has played 94 career matches at the US Open, if she progresses to the semi-finals she will become the third woman to reach 100 matches at the tournament (Chris Evert 113, Martina Navratilova 106).