The Toronto Blue Jays have moved to the top of the American League (AL) East after their second straight, series-sealing win over the Baltimore Orioles.
J.A. Happ struck out 11 batters while Kevin Pillar's four RBIs were a career high for the Blue Jays star.
The Chicago Cubs suffered a shock loss, going down 4-1 to the Seattle Mariners.
The Washington Nationals gave up an early lead as they went down 5-3 to the San Francisco Giants, who claimed their 60th win, while the Tampa Bay Rays were 6-3 winners over the New York Yankees and the Chicago White Sox earned a 6-5 win over the Minnesota Twins after 10 innings.
The Colorado Rockies beat the New York Mets 7-2, the Detroit Tigers edged the Houston Astros 3-2, the Cleveland Indians defeated the Oakland Athletics 6-3 and the Philadelphia Phillies triumphed over the Atlanta Braves 9-5.
Hernan Perez went three-for-four with three RBIs and a homer as the Milwaukee Brewers beat the Pittsburgh Pirates 5-3 in a series-clinching win, the Kansas City Royals lost to the Texas Rangers 2-1 and the Los Angeles Angels got the better of the Boston Red Sox 5-2.
The Miami Marlins crushed the St. Louis Cardinals 11-0, Adam Rosales hit a walk-off homer in the 10th to seal a 2-1 win for the San Diego Padres over the Cincinnati Reds and the Arizona Diamondbacks beat the Los Angeles Dodgers 4-2.
MILEY DOMINATES CUBS
Mariners ace Wade Miley flirted with a no-hitter against the Cubs before Chicago's Kris Bryant broke it up in the seventh inning. It was the only hit Miley allowed in seven innings while striking out nine and being charged with one earned run in Seattle's 4-1 victory at Wrigley Field. The Orioles could make a push on Sunday to acquire Miley.
Brewers hitter Perez was on form to put his side in the lead against the Pirates.
HAPP ON FORM
Toronto pitcher Happ struck out 11 over seven innings while dominating the Orioles. Happ improved to 14-3 this season and Saturday's start was an MLB-leading 66th quality start of the season for the Blue Jays' pitching staff.
ASTROS TAKE ON TIGERS
Houston hope to get a leg up on the Tigers with 2015 Cy Young winner Dallas Keuchel on the mound. Keuchel (6-10, 4.57) has struggled so far this season but did throw eight scoreless innings against the Tigers in April. Detroit will send Mike Pelfrey (3-9, 4.98) to the bump.