World number 16 Brooks Koepka will not play at The Open next week after tearing a ligament in his right ankle.
Koepka, who finished in a tie for 10th at last year's Open at St Andrews and will be replaced by Colt Knost, was hampered by the injury during the WGC-Bridgestone Invitational and was unable to finish his opening round.
He had hoped to have recovered in time for year's penultimate major at Royal Troon, but he has confirmed he needs further treatment on the problem to help him fully recover.
The 26-year-old is targeting a return at the PGA Championship at the end of July, which is this year being held at Baltusrol Golf Club in New Jersey.
After much consideration, I will unfortunately be withdrawing from next week's Open Championship. https://t.co/l6a0ZpcFVv-- Brooks Koepka (@BKoepka) July 9, 2016
"After much consideration, I will unfortunately be withdrawing from next week's Open Championship," Koepka announced on Facebook.
"I have a torn ligament in my right ankle that requires additional rehab over the next couple of weeks. This is the same injury that forced me to withdraw from the WGC-Bridgestone Invitational after 13 holes.
"I have been consulting with my doctor, trainer, and my entire team over the past week. We all feel this is the best decision at this time.
"I plan on making a full recovery over the next couple of weeks and returning at the PGA Championship.
"I wish everyone the best of luck next week at Royal Troon and I look forward to seeing everyone at Baltusrol."
Koepka's withdrawal hands 31-year-old Knost his major debut.