Andrea Iannone was comfortably fastest in free practice at the Italian GP in Mugello on Friday.
The Italian recorded a lap of one minute and 47.696 seconds, almost half a second quicker than his closest challenger - the man who will replace him at Ducati next season, Jorge Lorenzo.
MotoGP standings leader Lorenzo (Yamaha) was second fastest, 0.461secs off the pace.
Iannone's team-mate Michael Pirro (+0.549) was third to complete a good day for Ducati, while Suzuki's Aleix Espargaro rounded out the top four.
Marc Marquez of Repsol Honda and Valentino Rossi (Yamaha) - Lorenzo's closest title challengers - were fifth and sixth respectively as the Mugello circuit dried out.
Earlier in FP1, Aspar's Yonny Hernandez made good use of intermediate tyres in wet conditions, recording a leading time of 1:54.199, ahead of Scott Redding (OCTO Pramac Yakhnich) and Cal Crutchlow of LCR Honda.