Justin Rose has been forced to pull out of the BMW PGA Championship with a back injury.
The 2013 US Open champion struggled with the issue at the recent Players Championship, eventually finishing tied for 19th.
And the injury has now put paid to any hopes of glory at Wentworth.
"It is with deep disappointment that I must announce that I will not be able to play the BMW PGA Championship at Wentworth," he wrote in a statement.
"I battled the onset of back pain all week at The Players Championship, and symptoms worsened during my week after at home.
"I have a great team of people around me who are working diligently to help me get as fit as possible as soon as possible and I must fully focus on rehab at this time.
"I am incredibly sad to have to miss what I regard as my home event, particularly as it's a premier event on the European Tour schedule.
"Pending how I feel over the next several days, I am hopeful to make it out to Wentworth over the weekend to pay tribute to the tournament, volunteers, and spectators.
"I wish BMW, the European Tour and all the players a successful event, and I thank them and my fans for the continued support."