Leicester may have won the title but Newcastle is still battling it out with Sunderland and Norwich to stay outside the relegation zone.
Here we take a look at some interesting stats surrounding each of the weekend fixtures.
Norwich v Man Utd
Norwich are in desperate need of points but they need to make the most of the first half if they're to stand any chance here.
The Canaries have leaked goals at an alarming rate after half time, with the 17.8% of shots to have found the back of their net in the second half the highest in the division.
Manchester United's defence has looked noticeably less impressive away from Old Trafford, with their average of 18.9 shots faced for each goal conceded at home dropping to just 9.8 on the road, so there is hope for Alex Neil's side.
Aston Villa v Newcastle
Newcastle will surely be targeting three points here as they seek to remain outside the relegation zone, and against an Aston Villa side which has now lost 11 matches in a row they will surely kick off with plenty of optimism.
However, the Magpies are without an away win in their last 10 attempts - only their hosts have endured a longer run - so this will be another test of how much they've improved under Rafael Benitez.
The visitors have spent a smaller percentage of time winning than any other away side, clocking up just 5.8% of their playing minutes away from home while in the lead.
Bournemouth v West Brom
West Brom's most potent weapon this season has been their ability in the air, with over a third (34.4%) of their goals coming from headers; the largest share of any Premier League side.
Against Bournemouth their aerial prowess could be used to great effect, with the Cherries conceding from almost one in five (19.1%) of the headers they've faced: the highest percentage in the top flight.
Crystal Palace v Stoke
Stoke's season looks to be stuttering to a close, with only one win in their last eight Premier League matches, but a trip to an even more out-of-sorts Crystal Palace provides Mark Hughes' side with an opportunity to prove that their minds aren't already on the beach.
The Eagles have just one league win from their last 19 attempts and haven't scored more than once in any of their last 10 home games.
Sunderland v Chelsea
Sunderland remain in the relegation zone so have no choice but to play for the win here despite the likely task ahead of them.
Sam Allardyce's side have found outscoring their opponents difficult, as evidenced by six draws in their last eight Premier League matches, and the visit of Chelsea will generate little optimism.
The Blues haven't conceded more than once in any of their last nine away matches: the longest such run in the division by some distance.
West Ham v Swansea
West Ham's attackers have found another gear lately, having netted more than once in each of their last seven Premier League games; nobody else is on a run longer than two.
With Swansea opting to rest the previously ever-present Ashley Williams while Neil Taylor is also out injured, their less experienced back line could struggle to handle the in-form Hammers.
Leicester v Everton
This contest brings together the Premier League's two sharpest finishers, so it's fair to expect a few goals here.
The average of 8.2 shots taken by Everton for each goal that they've scored in the top flight this season can only be bettered by the Foxes' 7.4.
However, Everton's record against the division's leading sides has been woeful this season, with only four of their 44 points coming from their 11 matches against the current top six.
The Toffees didn't even get on to the score sheet in six of those encounters, although they managed to do so twice when Leicester beat them 3-2 at Goodison Park earlier this season.
Tottenham v Southampton
Suspensions look set to mar the end of Tottenham's impressive season after their ill-tempered draw with Chelsea, but they were already missing one of their most influential players.
Dele Alli is serving a three-match ban for violent conduct and Southampton should find Spurs easier to deal with as a result.
The hosts' scoring rate is far lower without Alli in the side: they register a Premier League goal every 42.4 minutes with him in the team but every 144.8 minutes when he's absent.
Liverpool v Watford
First half goals are unlikely to be in ready supply here given how organised these two defences have been at the start of their Premier League matches this season.
Both Liverpool and Watford have conceded one of the smallest percentages of goals before half time - little over a third of their totals at 35.4% and 35.7% respectively - so we could be made to wait for either net to bulge.
Man City v Arsenal
Arsenal's forwards have been starting matches far more fluently than City's defence this season, which could give the visitors an advantage early on.
The 13.9% of shots converted by the Gunners in the first half of matches is the joint-best in the top flight, while the 13.6% of opponents' efforts to have found the City net is among the three worst.