West Ham will bid farewell to Upton Park after they face Manchester United on Tuesday night, bringing to an end 112 years of history before their move to the Olympic Stadium.
Here, we look back at five memorable matches at the Boleyn Ground.
1. West Ham 3 Eintracht Frankfurt 1
Cup Winners' Cup semi-final, second leg. April 14, 1976.
A shade under 40,000 people packed into Upton Park to witness a Trevor Brooking masterclass on a quagmire of a pitch.
Trailing 2-1 from the first leg in Germany, West Ham were indebted to some fine saves from Mervyn Day to keep the game goalless on the night by half-time.
Then Brooking took over, hauling the Hammers level with a deft header to square the tie at 2-2 on aggregate. Keith Robson brilliantly grabbed another with a rocket into the top-left corner before Brooking glided into the box, dummied a defender with his left foot and beat the keeper with his right.
In typical West Ham fashion they endured a nervous finale after Frankfurt pulled one back but eventually triumphed 4-3 on aggregate in front of a delirious crowd. They went on to lose the final 4-2 to Anderlecht.
"I scored a couple in that one, one amazingly was a header as well, so the 1980 FA Cup final wasn't my only header," said Brooking. "The cup final was a defining moment for me, but at Upton Park against Frankfurt, under the lights, was a great experience."
2. West Ham 2 Ipswich 0
Championship play-off semi-final, second leg. May 18, 2004.
West Ham, looking to bounce back to the Premier League at the first attempt, trailed 1-0 from the first leg at Portman Road.
In the build-up to the match, manager Alan Pardew had urged the home crowd to play their part and by kick-off the old place was rocking.
Eight minutes after the interval the breakthrough came, Matthew Etherington collecting a short corner and firing in a superb angled drive.
The roof came off 19 minutes from time when Christian Dailly took a painful one for the team. A clearance whacked the Scotland defender in the midriff but he managed to lunge forward and prod the ball through a crowded goalmouth before collapsing to the ground in eye-watering agony.
"The goal was a painful memory," said Dailly. "I've looked back at it now and again and it was obviously worth it. The only thing was I wish I could have celebrated it a bit, but I just couldn't."
Unfortunately the Hammers went on to lose the final to Crystal Palace, but were promoted the following year via the play-offs - beating Ipswich in the semi-finals again.
3. West Ham 8 (eight) Sunderland 0
Division One, October 19, 1968.
Double hat-tricks at the Boleyn Ground have only occurred twice, and fittingly the only two West Ham players to achieve the feat are first and second in the club's all-time scoring charts.
Vic Watson had scored six of his 326-goal haul during an 8-2 thrashing of Leeds in 1929 - and nearly 60 years later it was repeated by Geoff Hurst, who scored 248 times for the Hammers.
There was more than a hint of handball about his first, but England's 1966 World Cup final hat-trick hero went on the grab a treble in each half of West Ham's biggest-ever top-flight victory.
Bobby Moore and Trevor Brooking were also on target, with Martin Peters and Harry Redknapp among those providing the ammunition.
"On a personal note that was my most memorable game at Upton Park," revealed Hurst. "My team-mate Brian Dear had only scored five against West Brom the season before, so I beat him!"
4. West Ham 3 Tottenham 4
Premier League, March 4, 2007.
It was often said of West Ham fans that they would rather see their team lose 4-3 than win 1-0. Although probably not to their fierce London rivals, and especially not while struggling against relegation.
Nevertheless West Ham obliged in a roller-coaster of a match which saw Carlos Tevez score his first goal for the club - a fine, curling free-kick - and jump shirtless into the crowd to celebrate.
Mark Noble also grabbed his first Premier League goal and Bobby Zamora looked to have secured a vital victory with five minutes remaining.
But Dimitar Berbatov hauled Tottenham level before Paul Staltieri hit a heart-breaking winner five minutes into stoppage time.
"It is a well known fact that I got a bit emotional after that game," recalled Noble. "I scored the opening goal, a half volley from outside the box. Then Carlos scored his first goal and jumped into the crowd. Then we end up losing 4-3. But that really kicked us on to go and stay up that year."
The defeat may have left them 10 points from safety but the performance seemed to galvanise the Hammers, who went on to win seven of their last nine matches to pull off a great escape.
5. West Ham 8 (eight) Newcastle 1
Division One, April 21, 1986
The match that made Alvin Martin the answer to a pub quiz question. The centre-half opened the scoring with a volley past Martin Thomas, the Newcastle goalkeeper who was clearly not fit.
Having seen efforts from Neil Orr, Ray Stewart and a Glenn Roeder own-goal fly past him, Thomas failed to emerge for the second half with defender Chris Hedworth taking over.
However, when Martin headed in his second, Hedworth collided with a post and dislocated his shoulder. That meant striker Peter Beardsley donned the keeper's jersey.
Frank McAvennie and Paul Goddard also got on the scoresheet before West Ham were awarded a penalty and the crowd bayed for Martin to take the spot-kick. He scored, completing a bizarre hat-trick past three different goalkeepers.
"To score a hat-trick on this ground past three goalies was a special night," admitted Martin. "Although people still say it's probably the worst hat-trick you'll ever see!"
Martin also recalled manager John Lyall being angry, despite his team being 7-1 up, that regular penalty taker Stewart did not do the honours as it could have affected West Ham's goal difference.