Parramatta Eels star Semi Radradra is in line to make his Australia debut after being named for the Test against New Zealand in May.
Radradra, 23, is eligible for the Kangaroos after living in Australia for three years, having previously made four appearances for the nation of his birth - Fiji.
He is joined by three other debutants - Blake Ferguson, Josh McGuire and Michael Morgan - for the Test in Newcastle on May 6.
Kangaroos coach Mal Meninga, preparing for his first game in charge, was delighted with the mix in his squad.
"This is a well-balanced squad and I'm extremely happy with it," he said.
"We have some experience as well as a handful of younger players who I am looking forward to seeing in this arena.
"It is the fourth most experienced line-up in Australia's Test history but there will also be four players making their debuts.
"This is an incredibly important game for this group. I want to ensure the players have pride in the national jumper and my goal is to establish the Kangaroos back at the top of the international rankings.
"We have a Four Nations tournament at the end of this year and then a World Cup in 2017. This is the start of an important journey for the Kangaroos."
Australia: 1. Darius Boyd, 2. Semi Radradra, 3. Greg Inglis, 4. Josh Dugan, 5. Blake Ferguson, 6. Johnathan Thurston, 7. Cooper Cronk, 8. Matt Scott, 9. Cameron Smith (c), 10. Paul Gallen, 11. Josh Papalii, 12. Matt Gillett, 13. Corey Parker.
Interchange: 14. Josh McGuire, 15. Michael Morgan, 16. James Tamou, 17. Sam Thaiday, 18. Aidan Guerra, 19. Michael Jennings.