Three-time RBC Heritage runner-up Luke Donald and Branden Grace share a one-stroke lead following Thursday's opening round.
It has been a tale of near misses for Donald but the former world number one looks set to be in the mix yet again after carding a five-under-par 66 alongside Grace at Harbour Town Golf Links.
Donald - who also has two third-placed finishes at the PGA Tour tournament - was almost faultless, shooting six birdies with the Englishman only dropping the eighth hole as he went bogey-free on the back nine.
"It was a pretty simple 66," said Donald. "I didn't have to scramble very hard and was able to just put it in good positions."
Grace enjoyed an identical round, with six birdies and a bogey to get the ball rolling following last week's Masters.
The pair are only a shot clear of world number one Jason Day heading into the second round.
After tying for 10th at Augusta, Day responded with a four-under-par 67, finishing with five birdies and one bogey.
That one bogey, unfortunately, came on his final hole, the difficult 18th, as he dropped a shot.
Matt Kuchar, who was champion in 2014, David Lingmerth and Tony Finau are level with Day.
Life as a professional got off to a decent start for Bryson DeChambeau at Harbour Town.
Competing as a professional for the first time after ditching his amateur status following the Masters, DeChambeau dropped just two shots, sinking three birdies on his way to a 70, four shots off the pace.
Two months on from a heart attack, Jason Bohn made his competitive comeback via a first-round 74.
Bohn, who left February's Honda Classic in an ambulance, had a mixed bag on the green, posting three birdies, four bogeys and a double-bogey.