A Shaun Kenny-Dowall double in his 200th NRL appearance for Sydney Roosters was unable to give Trent Robinson's struggling side a first victory of the season as Manly Sea Eagles fought back to win 22-20 at Allianz Stadium.
The Roosters have been minor premiers three years in a row, but that run will surely end this season as they sit bottom of the ladder after losing their first four games.
Robinson's men looked to be heading for a first win on Saturday when they took a 16-8 lead early in the second half, but Jamie Lyon's 14-point haul was enough to give Manly a second victory of the season.
Jorge Taufua gave Manly an early lead when he touched down after Latrell Mitchell dropped a high ball, but Kenny-Dowall marked his landmark appearance by going over twice either side of a Sio Siua Taukeiaho penalty to put the 10-8 up at half-time.
Sea Eagles forward Jamie Buhrer suffered yet another injury blow when he damaged his hand in the first half and his side were facing defeat when Blake Ferguson recovered from a blow to the wrist to go over out wide.
But Manly stunned the Rooters in a seven-minute spell which saw Dylan Walker score their second try before Lyon dotted down following good work from Tom Trbojevic and also slotted over a penalty after another mistake from teenager Mitchell.
Daniel Tupou's try reduced the deficit to two points, but Jackson Hastings failed to convert and Mitchell's misery was complete when he had a try ruled out when Mitchell Aubusson was offside so the Roosters' wait for a win goes on.
Gold Coast Titans produced a rousing late fightback to win 24-20 at Canberra Raiders and go joint-top of the ladder in the other game to be played on Saturday.
The Raiders GIO Stadium led 20-6 in the second half after Jarrod Croker had scored one of their three-first half tries and also added eight points with the boot, but the Titans refused to be beaten.
Converted tries from David Shillington and Zeb Taia reduced the deficit to two points with just two minutes remaining and Frank-Paul Nuuausala gave away a soft penalty to enable John Olive to snatch the victory.
However, the Titans must wait to learn if they will be punished following claims that they had 14 players on the pitch at one point in the second half.