Wales and Ospreys lock Alun Wyn Jones is facing six weeks on the sidelines due to a heel injury.
Jones has been left out of Warren Gatland's side to face Italy in their final match of the 2016 Six Nations at the Principality Stadium on Saturday, with Luke Charteris taking his place in the XV.
The head coach stated Jones has been struggling with the issue for a number of weeks and suggested he needs more than one month's rest in order to regain his fitness.
"Alun Wyn Jones has a foot problem that we have been managing for a while and he has played a lot of games," said Gatland.
"He has been operating at around 80 per cent and has dug in. We've taken the decision to give him a rest.
"He knows himself he's not quite where he has been in the past. He needs six weeks rest. It's making sure we manage him and work closely with the Ospreys and look at some conditioning.
"He's not where he was conditioning-wise because he hasn't been able to do it. Hopefully we can ease some of the issues with the foot. He's had it all of this campaign and a bit before.
"The injury came to a head after Saturday. He'd been getting through training but he went to the medics and said 'I'm struggling with my foot'.
"It's come to a head and that's why we've made the call to give him some rest. It would be pretty unfair on the Ospreys if we played him and then said to them he needs to miss your game."
A win over Italy on Saturday would ensure Wales finish second to England in the Six Nations.