The shocks continued to come at the Australian Open as another four seeds were dumped out in the second round, including former Wimbledon finalist Sabine Lisicki.
Denisa Allertova sent the 10th seed packingon Thursday with a 6-3 2-6 6-4 victory, while Timea Bacsinsky, Jelena Jankovic and Elina Svitolina were also beaten.
Third seed Garbine Muguruza had no such problems, though, as she coasted past Kirsten Flipkens, and she is joined in round three by two-time former champion Victoria Azarenka.
While Muguruza and Angelique Kerber sailed through in straight sets, it was the impressive display from Azarenka that caught the attention in Melbourne.
The 2012 and 2013 champion appears to be on her way back to the top of the women's game after struggling with injury, her latest signal of intent a 6-1 6-2 triumph over Danka Kovinic.
Ana Ivanovic - a former finalist at this event - is also through, although her 6-3 6-3 win over Anastasija Sevastova was halted for 26 minutes after a spectator fell in the stands.
SEEDS SAYING GOODBYE
A new generation of female players are making their mark this year and the latest to cause an upset was 18-year-old Naomi Osaka, the youngster's booming forehands too much for 18th seed Svitolina.
Along with Allertova and Osaka, Laura Siegemund and Annika Beck ended the hopes Jankovic and Bacsinszky respectively.
Siegemund mixed her game up superbly to down Jankovic, the world number 97 making 82 net approaches as she booked her first grand slam third-round match.
Madison Keys turned her match with Yaroslava Shvedova around in the second set, winning all her net points, hitting 11 winners and converting both break points.
Allertova only hit 19 winners in her victory over Lisicki, three fewer than her seeded opponent.
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Meanwhile, Lisicki was able to find a positive out of her early exit: "Was fighting my heart out there but lost in 3 sets! Great to be on court pain free but much more work ahead of me."
THEY SAID WHAT??
"It's completely different to when I started. I remember being seeded even myself would you get to third, fourth round without dropping too many games," said Ana Ivanovic on the challenges facing the seeds. "Now every match it's a battle and you just have to try and push yourself because it's all a challenge. They are young girls and they're fearless."
Azarenka has now won seven successive matches in 2016, but she is just focusing on the next one rather than her unbeaten form: "I want to keep improving from match to match. It's just only going to get tougher, so I really want to keep that focus and that intensity and that determination."
Two of Thursday's surprise packages - Siegemund and Beck - will come face to face in the third round, while Osaka's reward for beating Lisicki is a clash with Azarenka.
Johanna Konta - who beat Venus Williams in round one - will meet Allertova and 15th seed Keys is next up for Ivanovic.
First up in round three are Serena Williams against Daria Kasatkina, Maria Sharapova against Lauren Davis, plus Monica Puig versus fourth seed Agnieszka Radwanska.
Garbine Muguruza (3) beat Kirsten Flipkens 6-4 6-2
Angelique Kerber (7) beat Alexandra Dulgheru 6-2 6-4
Karolina Pliskova (9) beat Julia Goerges 7-6 (7-5) 6-1
Denisa Allertova beat Sabine Lisicki (10) 6-3 2-6 6-4
Annika Beck beat Timea Bacsinszky (11) 6-2 6-3
Victoria Azarenka (14) beat Danka Kovinic 6-1 6-2
Madison Keys (15) beat Yaroslava Shvedova 6-7 (4-7) 6-3 6-3
Naomi Osaka beat Elina Svitolina (18) 6-4 6-4
Laura Siegemund beat Jelena Jankovic (19) 3-6 7-6 (7-5) 6-4
Ana Ivanovic (20) beat Anastasija Sevastova 6-3 6-3
Ekaterina Makarova (21) beat Tatjana Maria 6-4 6-2
Varvara Lepchenko beat Lara Arruabarrena 7-6 (9-7) 6-4
Barbora Strycova beat Vania King 7-6 (7-5) 6-4
Johanna Konta beat Saisai Zheng 6-2 6-3
Madison Brengle beat Johanna Larsson 7-6 4-6 6-1
Shuai Zhang beat Alize Cornet 6-3 6-3