NFL owners approved a Rams move back to Los Angeles with the possibility that the San Diego Chargers eventually follow.
The Oakland Raiders, the third team considering relocation, withdrew their proposal.
In a 30-2 vote, league owners meeting in Houston endorsed the stadium proposal of Rams owner Stan Kroenke, who has plans to build a billion-dollar facility in the Los Angeles suburb of Inglewood.
The Chargers, who initially had a joint stadium proposal with the Raiders in Carson, California, have an option to join the Rams in Inglewood.
Before moving to St. Louis for the 1995 NFL season, the Rams were in Los Angeles from 1946-1994 after spending the franchise's first 10 years in Cleveland.
The Chargers were founded in 1960 as the Los Angeles Chargers before heading to San Diego the following year.
After the Raiders bowed out of a potential move, the Rams' switch became a simple matter of the proverbial rubber stamp.
The Rams said last month in their relocation application that a move to Los Angeles would be effective for the 2016 season.
A final decision on the Chargers could wait until a June vote in San Diego on public funding.
One thing is certain, the Rams will not be playing in Los Angeles alone after a Rams-only option was removed from the owners' ballot.