All eyes will be on Buffalo Bills coach Rex Ryan on Thursday when he takes his new team to the Meadowlands to face his old team.
Ryan said he expects New York Jets fans to wave "with one finger" and plans to make former Jets defensive lineman IK Enemkpali -- the player who broke the jaw of quarterback Geno Smith -- a pre-game captain.
There probably won't be a lot of points scored Thursday night, with both teams boasting solid defences and offences typically struggling on Thursdays, given the short week to prepare.
The Jets will again have Ryan Fitzpatrick under centre despite torn ligaments in his left hand. Bills quarterback Tyrod Taylor appears to be fully healthy after being hampered by a knee injury. Taylor and Sammy Watkins could pose problems for a Jets defence that has surprisingly been vulnerable through the air this season.
Sunday's slate features three top teams being tested on the road.
New England Patriots (8-0) at New York Giants (5-4), 4:25 p.m. ET
The last time the Patriots started a season 8-0, they reached the Super Bowl undefeated only to fall to Eli Manning and the Giants.
The Patriots were finally able to win the franchise's fourth Super Bowl last season and are in the middle of what could be another special year. Beating the Giants at the Meadowlands could exorcise some demons.
The Giants have been a tough team to figure this season, with stellar games followed by clunkers. Fourth-quarter collapses have been the biggest problem for the Giants, who must put together a complete game against the Patriots team that has looked invincible.
Minnesota Vikings (6-2) at Oakland Raiders (4-4), 4:25 p.m. ET
Teddy Bridgewater and Derek Carr were the NFL's top two rookie quarterbacks last season. Both are expected to lead their respective teams Sunday at O.co Coliseum.
Vikings QB Bridgewater suffered a concussion Sunday against the St Louis Rams but has passed protocols this week. While Bridgewater has been solid this season, the Vikings are relishing an excellent season from running back Adrian Peterson, who has 758 yards and four touchdowns through eight games after playing in just one game last year.
If the Vikings can win in Oakland, they will match their win total from last season.
Carr has been on fire this season with 2,094 passing yards and 19 touchdown passes to only four interceptions. His go-to target has been rookie receiver Amari Cooper, who leads the team with 653 receiving yards on 45 catches. Former 49ers receiver Michael Crabtree has seen a resurgence across the Bay. He has a team-high 47 receptions for 591 yards and five scores.
Arizona Cardinals (6-2) at Seattle Seahawks (4-4), 8:30 p.m. ET
The Sunday night match-up is a pivotal one in the NFC West. Both teams are coming off their byes, something the Seahawks needed to regroup for the second half of the season.
The Seahawks have reached the Super Bowl the last two seasons, winning it two years ago, on the strength of their defence and running game. While the Seahawks have the third-ranked rushing offence, Pro Bowl back Marshawn Lynch has battled injuries this season and has just one 100-yard game. Quarterback Russell Wilson is the team's third-leading rusher with 303 yards, just 73 behind rookie Thomas Rawls.
While it's been a committee rushing attack for the Seahawks, Cardinals running back Chris Johnson has found the fountain of youth in the desert. The former Tennessee Titans and Jets tailback is the NFL's third-leading rusher through nine weeks with 676 yards. The eight-year veteran who ran for 2,006 yards in 2009, has four 100-yard rushing games this season for the first time since 2012.
The game will likely come down to the quarterbacks and that's where the Cardinals have the advantage. Wilson is on pace to get sacked more than 60 times this season while Cardinals quarterback Carson Palmer has 20 touchdowns and six interceptions to lead an offence that is second in scoring and third in yards.