Younis Khan was overshadowed by Mohammad Hafeez in his final one-day international as Pakistan continued where they left off in the Test series with an emphatic six-wicket win over England.
Younis announced ahead of the first game of the four-match series in Abu Dhabi that this would be the 265th and final ODI of his career, having been recalled after being dropped following the Cricket World Cup.
The 37-year-old batsman fell for only nine in his final ODI innings, but Hafeez made a brilliant unbeaten 102 and Babar Azam 62 not out as Pakistan got home with 38 balls to spare after England made only 216 all out.
Reece Topley (3-26) claimed his first ODI wickets in his second appearance to give England hope, but Hafeez shone again after scoring a crucial century in the third Test and Azam also starred in an unbroken century stand.
Captain Eoin Morgan (76) and James Taylor (60) had earlier rescued England, but they lacked support at the Sheikh Zayed Stadium.
England got off to a dreadful start after Morgan won the toss as the impressive Mohammad Irfan (3-35) bowled Jason Roy (0) second ball and Joe Root (0) fell to Anwar Ali (2-32) in the next over.
The tourists were 14-3 when Alex Hales (10) was on his way, but Morgan and Taylor put on 133 for the fourth wicket to seemingly put them on course for a challenging total.
Morgan looked to be heading for three figures as he played with a combination of power and precision until he was caught behind off Shoaib Malik (2-45) after Taylor had been dropped from the previous delivery.
Jos Buttler's woes continued when he was run out in the same over for one, and Shoaib struck again to end a knock from Taylor that included two sixes and three fours as England fell to pieces.
It was left to Chris Woakes (33) to ensure the tourists made over 200, but their total was never going to be enough despite a poor start from Pakistan.
Topley trapped Azhar Ali (8) and Bilal Asif (2) leg before to reduce the hosts to 15-2, then Younis was given a great reception after the left-arm quick had dismissed him cheaply to leave Pakistan on 41-3.
Hafeez continued on his way and brought up half-century by hitting Adil Rashid for six and 21-year-old Azam showcased his talents in a run-a-ball knock that showed his great promise after Shoaib (26) was dismissed by Moeen Ali (1-32).
Azam cleared the ropes four times, while Hafeez struck 11 boundaries and fittingly hit the winning runs to put Pakistan 1-0 up.