Theresa May has revealed that she and her husband were "affected" by not being able to have children, but said it was just "one of those things".
The Home Secretary, hot favourite to take the helm of the Tory party in the leadership battle, has spoken about her struggle to conceive, in an interview with the Mail on Sunday.
She said she and her husband Philip found comfort in their happy marriage and from other things in their lives that they were "blessed with" when they found out they could not have children.
"Of course we were both affected by it. You see friends who now have grown-up children, but you accept the hand that life deals you," she told the paper.
"Sometimes things you wish had happened don't or there are things you wish you'd been able to do, but can't. There are other couples in a similar position."
The couple met while they were studying at Oxford University and were introduced at a Conservative Association dance by the late Pakistani prime minister Benazir Bhutto.
May said they wanted to have children but found they could not, adding: "It just didn't happen, so you know, it's one of those things."
Declining to reveal details about the help they sought for their fertility problems, she added: "I'm a great believer that you just get on with things.
"There are lots of problems people have. We are all different, we all have different circumstances and you have to cope with whatever it is, try not to dwell on things."
Married for 35 years, when asked whether his wife would make a good prime minister her husband, who works in the City, said: "She would be excellent, she always stays calm."