A campaign to save the life of a man with a rare type of leukaemia has just days to raise £400,000 to send him to the US for revolutionary treatment.
Kate Brandon, 33, has so far raised more than £250,000 towards the costs of her husband Mike's treatment at the University of Pennsylvania.
Kate has launched the #donate4Mike campaign on social media to raise the money for her 31-year-old husband's treatment, due to begin next Tuesday.
His treatment is funded by the university. But medical costs associated with its administration must be self-funded.
It's the second time the couple, from Bristol, have appealed directly to the public for help after Mike was diagnosed with acute lymphoblastic leukaemia in 2014 - a month after proposing to his now wife.
A matching donor was found and Mike underwent a successful transplant on his 30th birthday.
Mike has battled through the rejection of multiple anti-cancer drugs, undergone more than 20 gruelling bone marrow biopsies, contracted pneumonia and received five further infusions of cells from his donor.
Last summer the couple married - but sadly Mike relapsed at Easter.
In a video posted on their gofundme page, Kate said: "I now reach out to you again because Mike has relapsed but this time things are a hell of lot more worse than they were first time round.
"He relapsed at Easter and has very little hope for a full recovery. His only chance is to access this new research trial in America which is looking at CAR T-cell therapy.
"To get him there I need at least £400,000 and I need it as soon as possible.
"I know from the amount of support we had for #Shake4Mike and I know how serious things felt back then we were able to get through it. I know with your help we can get through it again."
People all over the world have been donating overnight. And even more money has been raised since Kate posted a thank you message on the #donate4Mike Facebook page early on Friday.
Kate said any extra money donated on the fundraising page will go to the Bristol Royal Infirmary haematology oncology unit.