Tobey Maguire and Jennifer Meyer have separated after nine years of marriage.
Tobey's representative confirmed a People magazine report on the breakup and told the magazine in a joint statement that the decision came "after much soul searching and consideration."
Tobey and Jennifer said their "first priority remains raising our children together with enduring love, respect and friendship".
The couple have a nine-year-old daughter, Ruby, and a seven-year-old son, Otis.
Jennifer is a jewellery designer and the daughter of Hollywood executive Ron Meyer.