Jennifer Aniston's longtime friend Chelsea Handler has weighed into the Brad Pitt split - calling Angelina Jolie a "lunatic".
Brad's ex-wife Jennifer - who was married to the heartthrob when he met Angelina on the set of the film Mr & Mrs Smith - has kept quiet about the divorce.
But US comedian Chelsea, 41, was not afraid to speak her mind on her self-titled Netflix talk show.
"Brad and Angelina always said they wouldn't get married until everyone could get married," she said, referring to the then couple's pledge not to wed until same-sex couples could tie the knot across the US.
"And I always said I wouldn't get married until they got divorced. So I'm officially accepting proposals. I'm ready!" she said.
Chelsea said of the warring couple and parents of six: "There are rumours that part of the problem was Brad was allegedly drinking and smoking too much weed.
"I wonder why he needed to self-medicate? Maybe because he could have been spending the last 12 years at Lake Como hanging out with George Clooney and Matt Damon, instead of being stuck in a house with 85 kids speaking 15 different languages?
"Oh yeah, because he married a f****** lunatic, that's why!"
Chelsea added: "But we should all respect their privacy during this very difficult time. So, this will be the last time I speak of this ... on TV. You can follow me on Twitter."
The chat show host couldn't resist later joking on Twitter:
Angelina Jolie has filed for divorce from Brad Pitt... he wants the China; she wants Pax and Maddox. ##sorrycouldnthelpmyself
-- Chelsea Handler (@chelseahandler) September 21, 2016
Ex-Friends star Jennifer was married to Brad for five years before she filed for divorce in 2005.
Pictures surfaced shortly afterwards of Brad on holiday with Angelina and her adopted son Maddox.
Jennifer wed actor Justin Theroux last year.