Celebrity Big Brother contestants Marnie Simpson, Renee Graziano, James Whale and Stephen Bear have been nominated for eviction.
Marnie, Renee and James were chosen by the housemates saved by the last public vote to face eviction in so-called "killer nominations", which were delivered face-to-face in Wednesday night's episode.
Ex On The Beach star Bear, who escaped the boot on Tuesday, opted for Renee, saying: "I'm not being funny, very negative."
After her nomination, Renee said: "I've got a mouth sharper than a motherf****** sword. I don't want to hug anybody. This is not so serious, I get to go home to my kids. That boy, at home, would roof my house."
The Only Way Is Essex star Lewis Bloor chose James, saying: "I believe he's a threat in the house and is doing very well in here. He's a very capable housemate and if he's not put up for nomination could go all the way."
Storage Hunters UK star Heavy D chose Geordie Shore star Marnie, saying: "I don't think you're a nice person. I don't like you."
Bear will face the public vote every week because he has an external nomination.
Later in the episode, housemates were shocked when Chloe Khan performed a topless pole dance before throwing cake with Bear, Marnie and Lewis in the bedroom.
This prompted James, Samantha Fox, Frankie Grande, Katie Waissel and Ricky Norwood to threaten to leave.
In the Diary Room with the group, James said: "We can't go on like this ... we all want to leave. There are four protagonists and they have overstepped the line tonight.
"This could be the first strike in the history of Big Brother and I'm very right wing!"
At the end of the episode it was revealed that the nominated housemates will have a chance to save themselves from the chopping block in Thursday's show.
Celebrity Big Brother is on Channel 5 at 9pm.