Sherrie Hewson broke down in tears as she announced she was leaving Loose Women after 14 years on the ITV show.
The Benidorm actress, 65, made the announcement live on the daytime show, prompting an emotional response from her fellow panellists.
"Loose Women is in my DNA," she said.
"I have a thing that goes right through my body that says Loose Women, like a rock in Blackpool, and so it will never, ever leave me."
She added: "On my seat, I've told everything. I've said everything...
"I've told as much as I'm sure you will want to hear. So I'm going to be leaving Loose Women because it's kind of time...I've said everything there is.
"I'm leaving this seat so somebody else now can sit on this seat for 14 years and tell all their stories."
But, she added, "like Arnold Schwarzenegger said, 'I'll be back'."
Sherrie said that she would "never forget" the support she had received from her fellow panellists, helping her through the collapse of her marriage, bankruptcy and a period of stress which caused her hair to fall out.
"We all care about each other. We all look after each other. We go out together, we get drunk together, we party, but we all care," she said.
"We've all been there for each other and stood by their side and made sure that they're OK".
An emotional Andrea McLean said: "You were so brilliant to me when my marriage was ending...you were the one that gave me the strength to leave."
Sherrie's colleagues promised "a good send off" before she leaves on September 5th.