It started as a small gathering of comic book fans back in 1970, but now Comic Con has become the main showcase for movie studios providing the very latest on some of Hollywood's most eagerly anticipated blockbusters.
Here we look at the must-see panels across the four-day event in San Diego.
Snowden - Thursday
Oscar-winning director Oliver Stone and actor Joseph Gordon-Levitt will present their new film Snowden, the story of NSA whistleblower Edward Snowden, who is also expected to appear via the internet for a question and answer session.
The film will be released in the US on September 16, with a UK release yet to be announced.
Warner Bros Presentation - Saturday
Warner Bros will showcase a number of eagerly anticipated films at the convention's 6,500-seat Hall H on Saturday.
Suicide Squad, starring Will Smith, Jared Leto and Margot Robbie will feature at the event, while Chris Pine and Gal Gadot will provide updates on the new Wonder Woman film.
Tom Hiddleston and Oscar-winning actress Brie Larson are expected to preview Kong: Skull Island and Eddie Redmayne and Colin Farrell will provide a further glimpse at the Harry Potter spin-off Fantastic Beasts And Where To Find Them.
-- Suicide Squad (@SuicideSquadWB) July 20, 2016
There are also appearances expected from The Lego Batman Movie director Chris McKay and star Will Arnett, and Charlie Hunnam, who plays the title role in Guy Ritchie's epic King Arthur: Legend Of The Sword.
Star Trek 50th anniversary - Saturday
Celebrating 50 years of the Starship Enterprise, original Captain Kirk actor William Shatner will be joined by some of the stars of the Star Trek spin-off series, including Scott Bakula, who played Captain Jonathan Archer in Star Trek: Enterprise.
The conversation will be moderated by Bryan Fuller, the executive producer of the new Star Trek TV series due to air in the US next year.
Aliens 30th anniversary - Saturday
Writer and director James Cameron will join cast members Sigourney Weaver, Bill Paxton, Lance Henriksen, Michael Biehn and Paul Reiser to celebrate the 30th anniversary of the film, widely hailed as one of the best sequels ever made.
Marvel Studios - Saturday
"You wonder what I see in your future? Possibility." pic.twitter.com/8IVll143VK
-- Doctor Strange (@DrStrange) April 13, 2016
Marvel Studios is expected to provide a first look at Guardians Of The Galaxy Vol 2 starring Chris Pratt, and previews of Dr Strange starring Benedict Cumberbatch, Spider-Man: Homecoming and Thor: Ragnarok. Benedict is reportedly confirmed to attend.
Sherlock - Sunday
The show's creators Mark Gatiss and Steven Moffat will join Amanda Abbington, who plays Mary Watson, to discuss the latest adventures of Sherlock Holmes and Dr John Watson. Steven recently warned that the next series could be the last as the stardom of Benedict continues to grow.
Fox's Action Showcase: Prison Break and 24: Legacy - Sunday
Corey Hawkins, who played Dr Dre in Straight Outta Compton, is the new hero in 24: Legacy, while Wentworth Miller will discuss his return to Prison Break - seven years after his character's apparent death.
Pokemon Go - Sunday
The popularity of gaming app Pokemon Go has seen its panel on Sunday move to the convention's largest room, Hall H, to accommodate fans. John Hanke, founder of Niantic, the makers of the game, is expected to speak.
Fans will have to make good use of their time to catch all the panels, with Game Of Thrones, The Walking Dead, The Rocky Horror Picture Show and The Exorcist TV shows also featuring.