Drake said he felt "disheartened" and "truly scared" after watching a video of the police shooting of Alton Sterling, whose death has prompted outrage and protests across America.
The One Dance singer expressed deep concerns about the "strained" relationship between communities of colour and the police as he mourned Alton's death.
Alton, 37 and a father-of-five, was shot by police in Baton Rouge, Louisiana, on Tuesday, following a confrontation outside a convenience store where he was selling his CDs.
Drake wrote: "Last night when I saw the video of Alton Sterling being killed it left me feeling disheartened, emotional, and truly scared. I woke up this morning with a strong need to say something."
"It's impossible to ignore that the relationship between black and brown communities and law enforcement remains as strained as it was decades ago. No one begins their life as a hashtag. Yet the trend of being reduced to one continues."
He is one of many celebrities to speak out against the deaths of Alton and Philando Castile, a black man in Minnesota who was shot dead by police during a traffic stop, the video of which has emerged in the aftermath of Alton's shooting.
Nicki Minaj shared the names of some of the people killed by police who had been the subject of the #BlackLivesMatter hashtag.
She wrote: "Will there be a conviction now? Probably not. #RIPAltonSterling hug the ppl u love a little tighter.... tell them you love them a little more often.
Kanye West just shared a video of the shocking shooting of Alton.
Katy Perry did the same, tweeting, "You can't just go on with your day, you must watch this & we must face this continual outrageousness."
Rihanna shared a video on her Instagram account of a woman discussing the #BlackLivesMatter campaign with her children in the car, and saying, "How often do we let someone else's child be a hashtag? You mad yet?"
Rihanna captioned it, "RIP Alton Sterling #howmanymore."
Kelly Rowland shared an image on Instagram of Alton's name, writing, "What's the excuse this time? This is ridiculous! Sad, ANGRY, and disappointed in a system that is suppose to protect...NOT kill."
Justin Timberlake tweeted, "HAS. TO. STOP. Devastating."